منابع مشابه
Fibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control
BACKGROUND As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic. Their enigmatic propensity to resist therapy and progress to organ failure has focused attention on the myofibroblast-the primary effector of the fibroprolifera...
متن کاملDNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys.
Renal erythropoietin-producing cells (REPCs) remain in the kidneys of patients with chronic kidney disease, but these cells do not produce sufficient erythropoietin in response to hypoxic stimuli. Treatment with HIF stabilizers rescues erythropoietin production in these cells, but the mechanisms underlying the decreased response of REPCs in fibrotic kidneys to anemic stimulation remain elusive....
متن کاملMechanical coupling between myofibroblasts and cardiomyocytes slows electric conduction in fibrotic cell monolayers.
BACKGROUND After cardiac injury, activated cardiac myofibroblasts can influence tissue electrophysiology. Because mechanical coupling through adherens junctions provides a route for intercellular communication, we tested the hypothesis that myofibroblasts exert tonic contractile forces on the cardiomyocytes and affect electric propagation via a process of mechanoelectric feedback. METHODS AND...
متن کاملInteraction between myofibroblasts and stem cells in the fibrotic heart: balancing between deterioration and regeneration.
Signalling between the various cell types in the heart has been investigated for decades. However, relatively little is known about the interplay between the cardiac fibroblasts and myofibroblasts, which help to maintain myocardial tissue structure and function, and resident cardiac or extracardiac stem cells involved in tissue homeostasis and repair. Much of our knowledge about these interacti...
متن کاملAlveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung.
Earlier work from this laboratory showed that abnormal fibroblast phenotypes isolated from fibrotic human lung produce factor(s) capable of inducing apoptosis and necrosis of alveolar epithelial cells in vitro [B. D. Uhal, I. Joshi, A. True, S. Mundle, A. Raza, A. Pardo, and M. Selman. Am. J. Physiol. 269 ( Lung Cell. Mol. Physiol. 13): L819-L828, 1995]. To determine whether epithelial cell dea...
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ژورنال
عنوان ژورنال: Current Pathobiology Reports
سال: 2013
ISSN: 2167-485X
DOI: 10.1007/s40139-013-0025-8